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Abstract
Objectives: To describe the current status of medication adherence and identify several associated factors among patients with Crohn’s disease at the Gastroenterlogy and Hepatology center, Bach Mai Hospital.
Subjects and methods: A cross-sectional descriptive study was conducted on 63 patients diagnosed with Crohn’s disease who were treated with biologics and/or immunosuppressants at the Gastroenterlogy and Hepatology center, Bach Mai Hospital, from January 2025 to December 2025. Medication adherence was evaluated for all patients using the 8-item Morisky Medication Adherence Scale (MMAS-8).
Results: Based on the MMAS-8, the overall medication adherence rate was 61.9%. While the rate of full compliance (taking medication “yesterday”) was relatively high at 87.3%, up to 84.1% of patients reported difficulty strictly following the treatment regimen. The rate of forgetting medication within the past two weeks was 39.7%, and 7 cases reported self-adjusting (reducing) the dosage or discontinuing use due to perceived worsening of health. Overall, 68.3% of patients occasionally or frequently experienced difficulty remembering to take their medication. The medication adherence rates in the age group under 25, those with university or postgraduate education, urban residents, and students were 6.5, 3.3, 15.7, and 5.8 times higher, respectively, compared to other groups (p < 0.05).
Conclusion: Patients with Crohn’s disease demonstrated a moderate level of medication adherence. There were significant associations between high adherence rates and age group, educational level, geographic location, and occupation.
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References
Wan J, Zhou J, Wang Z, Liu D, Zhang H, Xie S, et al. Epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: Insights from the past two years. Chin Med J (Engl). 2025 Feb 25;138(7):763–776. doi: 10.1097/CM9.0000000000003542
Coward S, Clement F, Benchimol EI, Bernstein CN, Avina-Zubieta JA, Bitton A, et al. Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data. Gastroenterology. 2019;156(5):1345-53.e4. doi: 10.1053/j.gastro.2019.01.002.
Nguyễn Thị Luân. Nghiên cứu một số đặc điểm lâm sàng, cận lâm sàng và nội soi đại tràng trong bệnh Crohn [Luận văn Thạc sĩ]. Trường Đại học Y Hà Nội; 2020.
Cao Thị Hoàng Yến, Nguyễn Công Long, Vũ Hải Hậu, Phan Văn Thắng. Đặc điểm lâm sàng và cận lâm sàng của bệnh ruột viêm đặc hiệu tại Trung tâm Tiêu hóa - Gan mật, Bệnh viện Bạch Mai năm 2022-2023. Tạp chí Y học Việt Nam. 2024;543(10):55-9. https://doi.org/10.51298/vmj.v543i3.11516
Chu Thị Vân, Nguyễn Thị Chi, Đào Việt Hằng. Thực trạng tuân thủ dùng thuốc và một số yếu tố liên quan của bệnh nhân viêm ruột mạn tính tại Bệnh viện Đại học Y Hà Nội. Tạp chí Y học Việt Nam. 2024;544(2):259-63. https://doi.org/10.51298/vmj.v544i2.11865
Kishor R, Kumari S, Prakash R, Chaudhary N, Shyama S, Ahmad S, et al. An assessment of treatment compliance using the Morisky scale-8 tool in adult hypertensive patients of Eastern India. J Family Med Prim Care. 2024;13(3):924-31.doi: 10.4103/jfmpc.jfmpc_1416_23.
Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1785-94. doi: 10.1053/j.gastro.2011.01.055.
Peyrin-Biroulet L, Colombel JF, Louis E, Ferrante M, Motoya S, Panaccione R, et al. Shorter Crohn’s Disease Duration Is Associated With Better Clinical and Endoscopic Outcomes With Risankizumab in Phase 3 Studies. Gastro Hep Adv. 2024;3(4):539-50. doi: 10.1016/j.gastha.2024.02.008.
Đinh Thị Ngà, Nguyễn Cảnh Bình, Thái Doãn Kỳ, Nguyễn Lâm Tùng, Hoàng Kim Ngân, Phạm Minh Ngọc Quang, et al. Biểu hiện lâm sàng tại ruột và ngoài ruột của bệnh nhân viêm ruột mạn tại Bệnh viện Trung ương Quân đội 108. Tạp chí Y Dược lâm sàng 108. 2023;18(3):96-101. https://doi.org/10.52389/ydls.v18i3.1816
Chan W, Chen A, Tiao D, Selinger C, Leong R. Medication adherence in inflammatory bowel disease. Intest Res. 2017;15(4):434-45. doi: 10.5217/ir.2017.15.4.434
Yilmaz H. Young age and shorter duration of Crohn’s disease are associated with non-adherence to taking medication. North Clin Istanb. 2022;9(1):8-13. doi: 10.14744/nci.2021.08634
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